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KMID : 0363620090300020017
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Journal of Korean Oriental Medicine
2009 Volume.30 No. 2 p.17 ~ p.29
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Hexane Fraction of Zingiberis Rhizoma Crudus Extract Inhibits the Production of Nitric Oxide and Pro-inflammatory Cytokines in LPS-stimulated BV2 Microglial Cells
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Jung Hwan-Yong
Joo Ye-Jin
Jung Hye-Mi
Shin Woo-Jin
Seo Un-Kyo
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Abstract
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Objectives: The present study is focused on the inhibitory effect of the rhizome hexane fraction extract of Zingiberis Rhizoma Crudus (ginger hexan extract; GHE) on the production of inflammatory mediators such as NO, PGE2, and proinflammatory cytokines in lipopolysaccharide (LPS)-stimulated BV2 cells, a mouse microglial cell line.
Methods: We separated the hexane fraction from Zingiberis Rhizoma Crudus’s methanol extract. The inhibitory and anti-inflammatory effect of GHE was examined on microglial activation.
Results: GHE significantly inhibited the excessive production of NO, PGE2, TNF-α, and IL-1β in LPS-stimulated BV2 cells. In addition, GHE attenuated the mRNA expressions and protein levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and proinflammatory cytokines.
Conclusion: The anti-inflammatory properties of GHE may make it useful as a therapeutic candidate for the treatment of human neurodegenerative diseases.
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KEYWORD
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Zingiberis Rhizoma Crudus, ginger, BV2 microglial cell, nitric oxide, pro-inflammatory cytokines
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